Exp Gerontol. 1989;24(4):317-30.

Effect of centrophenoxine and BCE-001 treatment on lateral diffusion of proteins in the hepatocyte plasma membrane as revealed by fluorescence recovery after photobleaching in rat liver smears.

Zs-Nagy I¹, Ohta M, Kitani K.

Author information

Abstract

The average lateral diffusion coefficient of proteins (D) in the cell membrane of hepatocytes has been measured in liver smears by fluorescence recovery after photobleaching (FRAP), based on the so-called peroxide-induced autofluorescence (PIAF) deriving from the oxidation of riboflavin bound to membrane proteins. It has been previously shown that D displays a significant negative linear age correlation. The in vivo effects of two drugs were tested on this parameter. Young (2.7 months) and old (24-26 months) male rats received centrophenoxine (CPH) or a new drug (BCE-001) by either intraperitoneal (i.p.) injection or per os through a gastric tube for 26 to 42 days. D was measured on a double-blind basis in the hepatocyte plasma membrane of treated and control groups. The CPH and BCE-001 treatments did not affect the value of D in the young rats. However, the latter drug increased their growth rate. An increase of D in old animals was induced by treatment with either drug. When the drug effects in old rats were compared, BCE-001 proved to be more efficient than CPH, and at the same time was able to significantly retard the age-dependent loss of body weight characteristic of these animals at the age of approximately 2 years. Our results are in good accord with the predictions of the membrane hypothesis of aging as regards the role of properly placed OH. free radical scavengers in the improvement of membrane and overall cell function.

 

Results: 9

Select item 238215381.

Modified cisplatin/interferon α-2b/doxorubicin/5-fluorouracil (PIAF) chemotherapy in patients with no hepatitis or cirrhosis is associated with improved response rate, resectability, and survival of initially unresectable hepatocellular carcinoma.

Kaseb AO, Shindoh J, Patt YZ, Roses RE, Zimmitti G, Lozano RD, Hassan MM, Hassabo HM, Curley SA, Aloia TA, Abbruzzese JL, Vauthey JN.

Cancer. 2013 Sep 15;119(18):3334-42. doi: 10.1002/cncr.28209. Epub 2013 Jul 2.

PMID:

 

23821538

Free PMC Article

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Select item 224531432.

Metformin plus PIAF combination chemotherapy for hepatocellular carcinoma.

Petrushev B, Tomuleasa C, Soritau O, Aldea M, Pop T, Susman S, Kacso G, Berindan I, Irimie A, Cristea V.

Exp Oncol. 2012;34(1):17-24.

PMID:

 

22453143

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A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma.

Yeo W, Mok TS, Zee B, Leung TW, Lai PB, Lau WY, Koh J, Mo FK, Yu SC, Chan AT, Hui P, Ma B, Lam KC, Ho WM, Wong HT, Tang A, Johnson PJ.

J Natl Cancer Inst. 2005 Oct 19;97(20):1532-8.

PMID:

 

16234567

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Towards a consensus in rate versus rhythm control for management of atrial fibrillation: insights from the PIAF trial.

Grönefeld G, Hohnloser SH.

Card Electrophysiol Rev. 2003 Jun;7(2):113-7. Review.

PMID:

 

14618032

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Randomized trial of rhythm or rate control in atrial fibrillation: the Pharmacological Intervention in Atrial Fibrillation Trial (PIAF).

Hohnloser SH, Kuck KH.

Eur Heart J. 2001 May;22(10):801-2. No abstract available.

PMID:

 

11350085

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Select item 113077936.

[Rhythm or rate control in atrial fibrillation — Pharmacological Intervention in Atrial Fibrillation (PIAF): a randomized trial].

Scardi S, Mazzone C.

Ital Heart J Suppl. 2001 Mar;2(3):320-1. Italian. No abstract available.

PMID:

 

11307793

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Select item 111179107.

Rhythm or rate control in atrial fibrillation–Pharmacological Intervention in Atrial Fibrillation (PIAF): a randomised trial.

Hohnloser SH, Kuck KH, Lilienthal J.

Lancet. 2000 Nov 25;356(9244):1789-94.

PMID:

 

11117910

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Select item 97276868.

Atrial fibrillation–maintaining sinus rhythm versus ventricular rate control: the PIAF trial. Pharmacological Intervention in Atrial Fibrillation.

Hohnloser SH, Kuck KH.

J Cardiovasc Electrophysiol. 1998 Aug;9(8 Suppl):S121-6. Review.

PMID:

 

9727686

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Select item 92725389.

Atrial fibrillation: maintaining stability of sinus rhythm or ventricular rate control? The need for prospective data: the PIAF trial.

Hohnloser SH, Kuck KH.

Pacing Clin Electrophysiol. 1997 Aug;20(8 Pt 1):1989-92.